Have results, discussion on players, clubs and then league wide. I think good idea would be to have people who support various clubs (old ornery Columbus fan or the excitable Kansas City fan) to give some banter and inside look at how one who follows a club's situation differs from outsiders view.
A general discussion and humor tinged show about the league? I'd give it a shot. Have some character, but don't feel need to force it with awkwardness. Also, I think it is fine to chuckle at the league (bloopers) and still love it.