I can't see this being a good development for the champions. Preud'homme was a stabilizing figure in a club that has always been chaotic. They might be in for another very long wait for the next title with this. If they fail to get into the CL, expect a mass exodus of their young, talented players.
So what was the reason behind Preud'homme leaving? It's not like he's been in the job for long.. sure they just won but it's only 1 title. It sure smells like a manager-board rift.