Coronavirus Discussion Thread

Discussion in 'The Netherlands' started by Orange14, Mar 17, 2020.

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  1. There's something weird going on. Both in the States as in Europe vast numbers of people in the meat processing industry are infected with Corona.
    It's now in the Netherlands a major hazard for spreading again of the virus.
    In a factory they found 20% of the employed to be infected.
    Worrying about it they cannot trace all the contacts of those infected.
     
  2. Especially this part is of importance:
    "Timothy Caulfield, the Canadian professor of law at the University of Alberta, differentiates between cases where a scientist changes their mind based on new data, and circumstances where someone misrepresented their work, or falsified data."
     
  3. Twenty Dutch children in hospital with kawasaki syndrom.
    With eleven of them were found antibodies for corona.
    Several of them ended up on the iC.
    4 patients were younger than 5. The rest ranged from 5 to 18.
    There's no cure for kawasaki.
     
  4. Second case of covid infection vai minks.
    Mink farmers are asking for the gouvernment to cull the mink population of farms with infected animals.
     
  5. nfitz

    nfitz Member

    Aug 20, 2007
    Toronto
    Canada too ...

    it's been the source of most of the issues in Alberta for some time - they've taken longer to eliminate community spread than most other provinces.

    Surely the meat packing industry isn't the only one where people need to work in close quarters ...
     
  6. Orange14

    Orange14 Moderator
    Staff Member

    Apr 27, 2007
    Bethesda, MD
    Club:
    AFC Ajax
    Nat'l Team:
    Netherlands
    No, but it is the one industry that has been working during the pandemic.
     
  7. From another thread:
     
  8. Vetenarians are urging to cull minks in farms with corona infected animals and to order house arrest for cats and dogs in a cirkel of a certain radius around those farms.
    This all is needed in an attempt to prevent reservoirs/hiding places for the virus that at a given moment can break out again.
    We were world wide the first with a animal to human transfer of the virus and now we have the second one.

    Scientist warn for the danger of animals as a reservoir:
    https://nos.nl/artikel/2335054-voorkomen-dat-dieren-corona-reservoir-worden.html
     
  9. Wow.
    I reported some time ago thge antibody discovery of the combined research study of my Alma Mater Erasmus University and Utrecht University.
    They announced to expect the medicine based on it to be on the market within 6 months.
    We Dutch rule.
    https://www.erasmusmagazine.nl/en/2...s-mc-and-utrecht-university/?noredirect=en_US
    Corona medicine in the making after discovery Erasmus MC and Utrecht University
    Frank Grosveld, professor of cell biology at Erasmus MC, expects the first medicines to be ready in five to six months.

    [​IMG]
    Image credit: GuidoPijper
     
  10. Why they were ahead of the pack:
    https://www.erasmusmagazine.nl/en/2...ntastic-but-the-goal-is-still-to-help-people/
    “It’s precisely corona virologists like us that are in great demand at the moment, because only a few virologists have dedicated themselves to this disease. Coronaviruses have never been a major medical problem in the past. Now that they are, I’m getting thousands of e-mails from all over the world. Scientists, research institutes, companies, they all want to source knowledge from us because we have been doing research into the various coronaviruses for many years.”
     
  11. This remark of the researcher is very reassuring to me:
    "The remarkable thing about this antibody is that it reacts to a part of the virus that doesn’t mutate quickly"
     
  12. Orange14

    Orange14 Moderator
    Staff Member

    Apr 27, 2007
    Bethesda, MD
    Club:
    AFC Ajax
    Nat'l Team:
    Netherlands
    Eli Lilly already has a similar monoclonal antibody in the clinic, Regeneron is about to start studies of their antibody this week.
     
  13. The Erasmus/Utrecht University thing is the only one aknowledged by peer review in scientific publications.
     
  14. What is important is the aknowledged fact the Erasmus/Utrecht antibody operates on a part of the virus that hardly mutates, something other antibodies lack as these are locking into parts susceptible to mutations during the reproduction of the virus.
    https://www.bigsoccer.com/threads/coronavirus-discussion-thread.2109411/page-12#post-38701563

    Now, even that RBD region has subregions. It’s 168 amino acids long, and that’s a pretty good amount of real estate. There’s a core domain that contains a smaller 60-residue exposed subdomain that loops out – that’s the part that first recognizes the ACE2 human protein. That is the tip of the spear: the receptor-binding loop region poking out of the receptor-binding domain of the Spike protein of the coronavirus. The problem is, if you target that particular region (which at first sounds like something you’d want to do) you run the risk of losing activity due to mutations, because that region is one of the more variable ones in the whole Spike. This 47D11 antibody, though, binds to the core domain of the RBD, which is much less variable, and that core-domain binding mode fits in with the way that it doesn’t seem to interfere with the ACE2 recognition event. And as the authors mention, this opens up the possibility of combining this antibody with another one that binds the exposed loop as a dual-acting therapy.

    The Erasmus/Utrecht antibody can be combined to increase the effectiveness!
     
  15. The Dam square George Floyd demonstration with about 5000 people close upon one another has sparked fury in our Parliament, from left to right and with medical staffs around the country who looked with horror to the event.
    Epidemiologists already branded it as a superspreadevent.
    What was baffling and disgusting was the way many black protesters talked about the corona situation. They stated it was subordinate to what happened in the USA.
    Those shitheads subordinate my health to something happening on the other side of the ocean.
    I really feel the urge to go to the centre of Rotterdam tomorrow and beat the crap out of those idiots.
    If in two weeks indeed a flash up appears and people die as a result these idiots better keep a very low profile for a very long time.
     
  16. Brilliant Dutch

    Brilliant Dutch Member+

    Ajax
    Netherlands
    Oct 14, 2013
    Amsterdam, Holland
    Nat'l Team:
    Netherlands
    Fauci says a vaccine is nearby: https://www.cnn.com/world/live-news...03-20-intl/h_d9360b4e277953a4490fa5ee17285938

     
  17. Orange14

    Orange14 Moderator
    Staff Member

    Apr 27, 2007
    Bethesda, MD
    Club:
    AFC Ajax
    Nat'l Team:
    Netherlands
    That's meaningless at this point in time. There are a lot of labs that have monoclonal antibodies right now. The technology is easy. I am not diminishing the performance of the Erasmus team but only putting it into context. The question is who they are partnering to produce this at scale for treatment. There a number of US biopharma companies who have this capacity. they also don't have to make public statements about their research. We will be surprised about the number of companies that eventually get into this field.
     

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