With the Brexit occuring, the landscape of the EPL could change significantly. As freedom of movement is clamped down upon, it may be that non-British European players will have to qualify for work-permits. This could help Americans move to the EPL, as they will be on more equal footing with the rest of Europe re: moving to the EPL. This could also hurt the quality of the EPL, because they will not be able to freely sign any European star. And just as the EPL's television deals seemed to certify the league's dominance for the forseeable future. In the end, tons of uncertainty as to what will happen, but it will be fascinating to watch.
Hope that Cameron (ours and theirs!) and Yedlin have being changing their Lbs as they go! US players just got 5-10% pricier, at least for the foreseeable future. And, of course, the "backdoor passport" for US dual may not work as easily if the WP rules change - although I would guess that the EPL has a lot of power and that Angerland is not likely to mess with it too much, unless the FA decides even less Euro players is better for the 3Lions.