After a loss to Inter today, and a loss to, I don't remember who, earlier, Palermo are now 11 points adrift of the last safe spot. They have 10 points total through 21 games. The chance that they more than double that in the remaining 17 games is extremely unlikely. Mathematical relegation likely won't happen for a while, but you can basically guarantee it. My only hope now is that Trapani finds a way to save themselves in Serie B to set up a Sicilian Derby. But seeing as they only just won their second game of the season, and are effectively 9 points from safety (they are currently dead last), that is also unlikely.