Had my 6 month teeth cleaning yesterday. Was required to wear a mask to the appointment and had my temperature checked. Other than that, it was the same as always. Had blood draw at my GP office earlier in the day. Same thing, mask required, temperature taken in the lobby before getting on the elevator.
What is important about the Dutch antibody is the aknowledged fact the Erasmus/Utrecht antibody operates on a part of the virus that hardly mutates, something other antibodies lack as these are locking into parts susceptible to mutations during the reproduction of the virus. https://www.bigsoccer.com/threads/coronavirus-discussion-thread.2109411/page-12#post-38701563 Now, even that RBD region has subregions. It’s 168 amino acids long, and that’s a pretty good amount of real estate. There’s a core domain that contains a smaller 60-residue exposed subdomain that loops out – that’s the part that first recognizes the ACE2 human protein. That is the tip of the spear: the receptor-binding loop region poking out of the receptor-binding domain of the Spike protein of the coronavirus. The problem is, if you target that particular region (which at first sounds like something you’d want to do) you run the risk of losing activity due to mutations, because that region is one of the more variable ones in the whole Spike. This 47D11 antibody, though, binds to the core domain of the RBD, which is much less variable, and that core-domain binding mode fits in with the way that it doesn’t seem to interfere with the ACE2 recognition event. And as the authors mention, this opens up the possibility of combining this antibody with another one that binds the exposed loop as a dual-acting therapy. The Erasmus/Utrecht antibody can be combined to increase the effectiveness!
Overall, daily positive cases in Indiana are down from 650ish to 300-400 for the last few days statewide, with single-digit deaths. My county in particular seems to be doing better than others, as we were second-highest in the state at first but have been passed by several since then. Went hiking yesterday in one of our state parks. Not many masks in evidence, though my family and I had them handy for the times we had to pass someone on the trail. One interesting thing was that probably half the people we were passing were Amish or Mennonites (judging by the clothes and the German they were speaking), and not a one of them had masks. All kinds of questions popped into my head but I didn't feel comfortable starting a conversation for various reasons. I'm still waiting for a day that the positive-to-tested ratio is under 10%. My fear is that we still have about the same rate of infected people running around out there, there are just fewer with symptoms. We only test people who present. So when the restrictions go away, it'll get ugly again.
The showers after a game were torture due to the scrapes. I won't even get into the rugburns from indoor.
Since the protests, covid-19 posts have gone from 6 ‘pages’ a day to “disappearing like a miracle.” Bunker Bitch got what he wanted from the media.
I live on a dead end street that has a creek at the end. On the other side of that creek is a hospital. At the other end of my street is a funeral home that is two doors down from my house. This funeral home also houses a crematory. Every time I look out my kitchen window or go into my yard, I can see the "smoke stacks" of the crematory. For the last 9 weeks, the fires at the crematory have been burning non-stop. I know this because you can see the heat rising from the stacks at any hour of the day or night. Living between these two places all I hear all day is ambulances and medical helicopters, and every time I go to my kitchen window or let the dog out, I see the heat from those stacks. It has been the most depressing time because I know that when the people die at that hospital, they are taken right to the crematory. It's equally depressing when your kids want to play out there in the shadow of those stacks, but they never ask what they're for. When I woke up this morning to let the dog out, the fires were off at the crematory. It was such a tremendous sight. For one day, things calmed down enough to provide a glimmer of hope that I wouldn't have to spend any more days thinking about the deaths of people I'll never know, and how their families may have never gotten to say goodbye. I fear that the reopening that is about to happen in the Philadelphia area is going to spike things, and I'll hear nothing but sirens and see nothing but the heat from the crematory, but it was actually nice, for once, to get a break from the despair.
What he got was being called Bunker Bitch and seeing his poll numbers tumble further. He's the dumbest politician who ever was. Once also the luckiest, but his fortunes looked to have changed.
As a former casino owner, Trump should know well that people's luck can change on a dime. I mean, he would know that better if he hadn't bankrupted said casinos.
And it's not like the Coronavirus news will be gone forever. When the protests are out of the news cycle, we'll still be at 100000+ deaths with hundreds of new deaths every day.
IC: “But Hillary would have had the same problems dealing with a Pandemic!!!” https://www.politico.com/news/2020/06/02/emergency-health-aid-coronavirus-297701 Months after Congress approved $175 billion in emergency aid to health providers, the Trump administration has yet to pay out the majority of the funds — nearly $100 billion — amid a series of setbacks and internal uncertainty over how best to distribute the money. The delay has prompted complaints by both Democrats and Republicans on Capitol Hill, and left the nation’s safety net hospitals and clinics with relatively little federal support during a pandemic that’s simultaneously thrust them onto the front lines and decimated their finances.
I wanted to go to the protests, it I’m high risk, and COVID19 is still a threat to me (and my wife). That being said, I’ve donated to organizations that support this. But to stay on topic, yes, I think CV19 has been eclipsed in the MSM by current events
My kids sneaked out to go to the protests. I'm the sole caretaker for my elderly mom who lives independently and we can't afford to risk her infection, so it caused us much consternation. I understand their wanting to do something however, so we were upset but not for long.
Back when that happened I still remember thinking how in the fooking hell you can do that? In a casino is simple all the math favors the house, it just absolutely boggles the mind.
If you spend an amount to buy the casino that requires 20,000 customers per week, but you're in a market where you get 10,000 customers per week, you lose.
Oops. Sorry, grandma & grandpa Sweden’s top epidemiologist, who persuaded country to not impose a strict lockdown, now says that approach caused too many deaths and he regrets it https://t.co/Biv7zQMxNC via @business @LussiD #Covid19 #GlobalHealth— André Picard (@picardonhealth) June 3, 2020
Anders Tegnell admitting (half-assed) the Swedish experiment didn't work: "If we would encounter the same disease, with exactly what we know about it today, I think we would land midway between what Sweden did and what the rest of the world did". The number of Covid19 deaths per capita in Sweden was the highest in the world in a rolling seven-day average to June 2nd, according to reported data. The country’s rate of 5.29 deaths per million inhabitants a day was well above the UK’s 4.48. https://t.co/6j9tfuVfjK pic.twitter.com/blVq4CkZGU— Scott Gottlieb, MD (@ScottGottliebMD) June 3, 2020 No wonder Denmark & Norway don't want to open up their borders to them.