Not really as long as their combo is providing good output. Valencia is good at bringing Rafa into the game.
I think we need another goal, early. We don't need to complicate things with a defensive lapse. Need to put this to bed. Nani also needs time with RvP and hopefully Kagawa too. I'd bench Antonio and drop Wayne back to CM, moving Giggs out wide with Nani to bring on one of Shinji or RvP. The reason I want to drop Wayne back, before anyone gets any ideas, is that he needs touches and to be involved and he needs to run a lot. He will take his customary few matches to get back into shape and maybe we can speed it along. Also, it isn't as though Giggs/Ando inspires me from a ball-winning or defensive standpoint.
Can see Ando gassing around the 60th minute, so hopefully we don't leave him on the pitch too long after that.
If at all possible, I'd like RVP, Carrick, Cleverley, Rio and Evra to have a full rest. If we can get a couple more goals early, get Rafa off as well. Not sure who is on the Bench?!! but kagawa could do with the minutes at some point.
Valencia and Young think beating a defender 1v1 is a myth. All they know is pass backwards or cross. Their is no third option (unless you count falling over...which Ashley Young does).